FAQs

PDRN stands for Polydeoxyribonucleotide. It's a chain of purified peptides derived from salmon DNA, 95% structurally identical to human DNA. Because of that identity, your skin recognizes it instantly and uses it as building material to rebuild its own collagen, elastin, and hyaluronic acid.

Most serums try to add ingredients to your skin from the outside — collagen, hyaluronic acid, vitamins. PDRN works differently: instead of adding, it signals your fibroblast cells to start producing their own collagen, elastin, and hyaluronic acid again. It's the difference between feeding someone a fish and teaching them how to fish.

Salmon DNA happens to share 95% structural identity with human DNA, which makes it the closest biocompatible source available at scale. The salmon used is food-grade and ethically sourced from existing fishery byproducts.

Yes. PDRN has been used in clinical injection form across Korean dermatology clinics since 2014, most commonly under the brand Rejuran. A single in-clinic session typically costs $400 to $800 USD. NEDA delivers the same molecule as a sealed topical ampoule for at-home use.

PDRN has been used in clinical medicine since the 1970s, originally developed for wound healing and tissue regeneration, and has been studied in over 200 peer-reviewed publications. It's approved by the Korean Ministry of Food and Drug Safety for both clinical injection and topical cosmetic use.

Yes. PDRN is one of the most extensively studied skincare ingredients available. Its biocompatibility comes from being nearly identical to human DNA, which means your immune system doesn't flag it as foreign.

The salmon DNA in our ampoules undergoes a purification process that removes all proteins and allergens. The final peptide chain contains no recognizable salmon material — no smell, no fish-derived risk. Most people with seafood sensitivities use it without issue. If you have a severe shellfish allergy, we recommend a patch test on your inner forearm before applying to your face.

PDRN has no known systemic risk and is considered safe for topical use during pregnancy and breastfeeding. As with any new product introduced during pregnancy, we recommend consulting your doctor before starting your cure.

PDRN is widely used in clinic specifically because it's gentle — Korean dermatologists use it post-laser and post-procedure to calm and repair skin. A mild tingling sensation during the first 3-5 nights is normal and subsides within a week. If irritation persists beyond 7 nights, discontinue use and contact us.

Yes. PDRN is often used in Korea specifically to support recovery after aesthetic procedures. Wait until any open or broken skin has healed (usually 48-72 hours), then resume your nightly cure.

The only common observation is mild tingling during the first 3-5 nights, which is the peptides activating absorption pathways in your skin. No long-term side effects have been documented.

No. PDRN is derived from purified salmon DNA, so NEDA is not vegan. We are cruelty-free and not tested on animals at any stage of formulation or production.

Most customers notice the first changes between day 7 and day 14 — typically softer texture, better hydration retention, and an early glow. Visible firmness and pore refinement usually appear between day 14 and day 21. Full cellular renewal results land by the end of the 30-night cure.

The 10-Day Starter is designed as a trial to let you experience the format and feel the first subtle changes. Visible transformation typically requires the full 30-night cure — PDRN works cumulatively, not instantly.

The most commonly reported changes after a full 30-night cure: firmer jawline, refined pores, softened fine lines, more even tone, plumper skin, and a lit-from-within glow. NEDA does not restore facial volume lost to fat reduction — it works on skin quality, not subcutaneous structure.

Your skin's improved barrier function and texture will continue to benefit for several weeks after stopping. For sustained results, most customers continue with monthly cures via subscription. Think of it like a workout — the benefits stay but compound with consistency.

We recommend at least two consecutive 30-night cures to lock in cellular renewal results. Many customers stay on monthly subscription after that as ongoing maintenance.

PDRN oxidizes the moment it meets air. A standard 30ml serum bottle loses up to 60% of its peptide activity within 4-6 weeks of opening. Single-dose ampoules stay 100% sealed and 100% active until the second you twist them open. It's not a packaging gimmick — it's chemistry.

Four steps, thirty seconds, every night for the length of your cure. Twist the cap until the seal breaks (you'll hear a small click). Pour the serum into your clean palm. Press into your face with your fingertips, working from the center outward. Wait 60 seconds, then layer your night cream on top.

Night. PDRN works best during your skin's overnight repair cycle and absorbs more effectively when undisturbed by makeup, sunscreen, or sweat.

Yes, but not in the same application window. Apply NEDA on its own at night, wait for full absorption, then layer your night cream on top. For best results, alternate retinol or high-dose vitamin C nights with NEDA nights rather than stacking them in the same evening.

No. Each ampoule is engineered for a single application. Once opened, the actives begin oxidizing immediately. Discard the empty ampoule in your recycling.

One missed night won't derail your cure. Just resume the next evening. PDRN's effects are cumulative, so consistency matters more than perfection — but missing 3 or more nights per week will slow your results.

We back every order with a 60-day money-back guarantee. If you've completed at least 14 nights and aren't satisfied, contact us for a full refund.

We currently ship across the United States with free shipping over $75. International shipping is launching soon — sign up to our list to be notified.

US orders ship within 1-2 business days and arrive within 3-5 business days via standard shipping.

Every NEDA order is backed by a 60-day money-back guarantee. If the cure doesn't deliver visible results for you, contact our team within 60 days of delivery for a full refund — no need to return the unused ampoules.

Email us at support@neda.com with your order number and a few words about your experience. Refunds are processed within 3-5 business days back to your original payment method.

For product questions, order issues, or anything else: support@nedaskin.com. We respond within 24 hours on weekdays, 48 hours on weekends. For press, partnerships, or wholesale inquiries: hello@nedaskin.com.